Newer laboratory parameters for the diagnosis of rheumatic disease
Identifieur interne : 003245 ( Main/Exploration ); précédent : 003244; suivant : 003246Newer laboratory parameters for the diagnosis of rheumatic disease
Auteurs : Steven Carsons [États-Unis]Source :
- The American Journal of Medicine [ 0002-9343 ] ; 1988.
English descriptors
- Teeft :
- American journal, Animal models, Anticardiolipin antibody, Anticardiolipin antibody syndrome, Anticentromere antibodies, Antinuclear, Antinuclear antibodies, Arthritis, Arthritis rheum, Assay, Autoantibody, Bacterial infection, Carson, Clin, Clinical immunology, Congenital heart block, Connective tissue disease, Connective tissue diseases, Crest syndrome, Disease activity, Erythematosus, Fetal loss, Fibronectin, Fibronectin levels, Further study, Glycoprotein, Glycoprotein variants, Hyde park, Immunosorbent assays, Instances redefinition, Long island jewish, Lupus, Medicine volume, Newer autoantibodies, Nonsteroidal drugs, Plasma fibronectin, Plasma fibronectln, Plasma form, Plasma glycoproteins, Reactant, Rheum, Rheumatic, Rheumatic disease, Rheumatic disease activity, Rheumatoid, Rheumatoid arthritis, Rheumatoid factors, Ribonuclear protein component, Screen serum, Serum antibodies, Smith antigen, Standard assays, Syndrome, Synovial, Synovial fluid, Synovial fluid fibronectin levels, Systemic, Systemic lupus erythematosus, Therapeutic intervention, Unexplained thrombotic episodes, Useful adjunct.
Abstract
Abstract: Measurement of serum autoantibodies is a useful adjunct in the diagnosis of connective tissue diseases. Approximately 15 percent of patients with rheumatoid arthritis are seronegative for rheumatoid factor by standard assays. The development of enzyme-linked immunosorbent assays for additional isotypic and idiotypic determinants may expand the diagnostic sensitivity of rheumatoid factor measurements. Although extremely sensitive, the finding of antinuclear antibodies is not highly specific for systemic lupus erythematosus and related disorders; the ability to rapidly screen serum against newly characterized specific nuclear antigens has been helpful in the diagnosis of newly described systemic lupus erythematosus subtypes, overlap syndromes, Sjögren's syndrome, and scleroderma variants. Women with unexplained recurrent fetal loss and patients with unexplained thrombotic episodes should be screened for the presence of the anticardiolipin antibody. Glycoproteins (C-reactive protein, alpha-1-glycoprotein, fibronectin) may prove useful as indicators of rheumatic disease activity and the efficacy of therapeutic intervention.
Url:
DOI: 10.1016/0002-9343(88)90360-9
Affiliations:
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Le document en format XML
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Approximately 15 percent of patients with rheumatoid arthritis are seronegative for rheumatoid factor by standard assays. The development of enzyme-linked immunosorbent assays for additional isotypic and idiotypic determinants may expand the diagnostic sensitivity of rheumatoid factor measurements. Although extremely sensitive, the finding of antinuclear antibodies is not highly specific for systemic lupus erythematosus and related disorders; the ability to rapidly screen serum against newly characterized specific nuclear antigens has been helpful in the diagnosis of newly described systemic lupus erythematosus subtypes, overlap syndromes, Sjögren's syndrome, and scleroderma variants. Women with unexplained recurrent fetal loss and patients with unexplained thrombotic episodes should be screened for the presence of the anticardiolipin antibody. Glycoproteins (C-reactive protein, alpha-1-glycoprotein, fibronectin) may prove useful as indicators of rheumatic disease activity and the efficacy of therapeutic intervention.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Carsons, Steven" sort="Carsons, Steven" uniqKey="Carsons S" first="Steven" last="Carsons">Steven Carsons</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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